Nossentthe influence of the 1997 updated classification criteria for systemic lupus erythematosus. The aim of this study was to compare the sensitivities of acr and slicc criteria in childhoodonset sle csle using a large, multiethnic cohort. I offer a mnemonic that contains the 11 categories used by the american college. Like many rheumatological diseases, systemic lupus erythematosus sle is difficult to diagnose owing to the constellation of findings required.
This study aimed to compare these criteria with the wellestablished american college of rheumatology classification criteria acr1997 criteria in a national cohort of juvenileonset systemic lupus erythematosus jsle patients and evaluate how patients classification criteria evolved over time. Validation of new systemic lupus erythematosus classification. Performance of the new slicc classification criteria in childhood systemic lupus erythematosus. Katarzyna gilekseibert, md abstract systemic lupus erythematosus sle is a chronic, compli cated and challenging disease to diagnose and treat. The systemic lupus international collaborating clinics slicc recently validated an alternative system. Classification criteria for systemic lupus erythematosus michelle petri, 1anamaria orbai. Use of slicc criteria in a large, diverse lupus registry enables sle. Jul 14, 2014 the most recent addendum to the classification criteria for sle dates from 2012, when the systemic lupus international collaborating clinics slicc group published a revision and validation of the acr criteria 5. This study aims to compare the performance among the american college of rheumatology acr 1997, the systemic lupus international collaborating clinics criteria slicc and the new european league against rheumatism eularacr criteria, in a csle cohort.
Pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. Objective currently there are 2 different classification criteria for systemic lupus erythematosus sle. Patients may be labelled as systemic lupus erythematosus sle in their medical records, when in fact they have cutaneous lupus. In an early sle cohort the acr1997, slicc2012 and eular. These criteria were developed and validated for the classification of patients with a longstanding established disease. Until now, classification of systemic lupus erythematosus sle was a yesorno decision, based on whether the patient had a minimum number of characteristic signs or symptoms. Slicc criteria but the 2015 acr slicc revised criteria can. Slicc criteria for sle slicc classification criteria for. American college of rheumatology acr and systemic lupus international collaborating clinics slicc. Pdf 2015 acrslicc revised criteria for diagnosis of systemic. Systemic lupus international collaborating clinics slicc criteria. The recent used diagnostic criteria widely used for sle is 2015 acr slicc revised criteria for diagnosis of systemic lupus erythematosus which is based on point systems.
This article provides more detail on the differences between classification and diagnostic criteria, and why the. In an early sle cohort the acr1997, slicc2012 and eularacr. Although the outlook for patients with sle has greatly improved, many unmet needs remain, chief of which is the development of safer and more efficacious therapies. The new criteria, which are on track for formal endorsement before the end of 2018 by the two medical societies that sponsored the revision, instead use a point system. In the validation set, the slicc classification criteria resulted in fewer misclassifications compared with the current acr classification criteria 62 versus 74. The use of slicc and acr criteria to correctly label. Because of the unknown diagnostic performance among patients from nephrology clinics, we aimed to. The acr has previously endorsed diagnostic criteria. Pdf 2015 acrslicc revised criteria for diagnosis of. State the classification criteria of lupus and their limitations when used for diagnostic purposes. A list of items considered to reflect damage in sle was generated through a nominal group from the systemic lupus international collaborating clin ics slicc and the american college of rheumatology diagnostic and therapeutic criteria committee. Systemic lupus erythematosus sle is a multiorgan disease.
Evaluation of the acr and slicc classification criteria in. Validation of the 2017 weighted criteria compared to the. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often. To develop new classification criteria for systemic lupus erythematosus sle jointly supported by the european league against rheumatism eular and the american college of rheumatology acr. Other criteria were chosen from 7 clinical constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, renal and 3 immunologic antiphospholipid antibodies, complement proteins, slespecific antibodies categories, and weighted from 2 to 10. Objective sle is traditionally classified using the american college of rheumatology acr criteria. New eularacr classification criteria for sle rheumnow. Novel paradigms in systemic lupus erythematosus the lancet.
This systemic lupus diagnostic criteria slicc calculator helps the classification and diagnosis of sle based on clinical and immunological criteria. Oct 22, 2015 pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. Another important aspect of the new slicc classification criteria is that biopsyproven lupus nephritis, in the presence of antinuclear or antidoublestrandeddna antibodies, is now sufficient. The systemic lupus erythematosus international collaborating clinics slicc group has recently proposed a revised classification criteria,10 which hopes to replace the 1997 american college of rheumatology criteria,11 to improve on the sensitivity and specificity table 1. Systemic lupus erythematosus, sle, sle nephritis, sle management, sle classification, acr vs slicc criteria, new drugs in sle. Systemic lupus international collaborating clinics. Slicc criteria for sle slicc classification criteria for sle. Alternative methods for sle classification have been developed predominantly in adults, such as the slicc systemic lupus international. Pdf performance of the new slicc classification criteria in. Sliccacr criteria dont id severe internal disease in scle. We compared groups of patients based on whether the slicc criteria were met before. In 2012, the slicc criteria were published in an attempt to improve clinical relevance of sle criteria. We compared the ability of the american college of rheumatology acr, systemic lupus erythematosus international collaborating clinics slicc and european league against rheumatism eularacr systemic lupus erythematosus sle classification criteria sets to provide information regarding organ damage and mortality, over a 10. If a patient meets at least four criteria, lupus can be diagnosed with 95% specificity and 85% sensitivity.
Some slicc criteria could not be applied some acute and chronic forms of cutaneous lupus, nonscarring alopecia, mononeuritis multiplex and complement values. The new 2019 eularacr classification criteria for sle requires a positive ana as obligatory entry criterion. The 2012 systemic lupus international collaborating clin ics slicc classification criteria addressed many of these issues. The american college of rheumatology has 11 classification criteria for lupus. Apr 26, 2014 systemic lupus erythematosus sle is a chronic inflammatory disease affecting a number of organs and organ systems 1,2.
Use of slicc criteria in a large, diverse lupus registry. The diagnostic accuracies of the 2012 slicc criteria and the. The recent used diagnostic criteria widely used for sle is 2015 acrslicc revised criteria for diagnosis of systemic lupus erythematosus which is based on point systems. Figure 1 natural history of systemic lupus erythematosus. To date there are no specific classification criteria for childhoodonset systemic lupus erythematosus csle. Evaluation of the slicc classification criteria in patients with. We compared the european league against rheumatism eularamerican college of rheumatology acr2019, systemic lupus international collaborating clinics slicc 2012 and acr1997 criteria in an early median 48 months systemic lupus erythematosus sle cohort. Derivation and validation of the systemic lupus international. New classification criteria for systemic lupus erythematosus. The systemic lupus international cooperating clinics slicc 2012 criteria increased sensitivity, but at the price of reduced specificity. Comparison among acr1997, slicc and the new eularacr. Objectives classification criteria are biased towards classifying longstanding disease. The slicc criteria are validated criteria for making the diagnosis of lupus. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and is especially prevalent among women of.
Derivation and validation of systemic lupus international. American college of rheumatology classification criteria for. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and is especially. Comparison of sensitivities of american college of. In the text below the form there is information on the slicc, along with instructions on how to interpret the criteria that is present. Toward new criteria for systemic lupus erythematosusa. The acr 1997 criteria were criticized for their suboptimal sensitivity. The american college of rheumatology acr classification criteria for lupus and systemic lupus international collaborating clinics slicc criteria are designed to classify disease. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and. In 2012, the systemic lupus international collaborating clinics slicc presented a new classification for systemic lupus erythematosus sle. Acrarhp annual meeting 20152009 meetings download abstracts. Wallace,8 ola nived,9 gunnar sturfelt,9 rosalind ramseygoldman,10 sangcheol bae,11.
The systemic lupus international collaborating clinics slicc damage index. Systemic lupus erythematosus sle is a chronic inflammatory disease affecting a number of organs and organ systems 1,2. Edi hidayat free download as powerpoint presentation. Slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. Conclusions the slicc criteria classify more subjects with sle than acr. We compared groups of patients based on whether the slicc criteria were met before, at the same time or after the acr were met. Different classification criteria for systemic lupus erythematosus sle have been proposed over many years.
Pdf performance of the new slicc classification criteria. The heterogeneity of systemic lupus erythematosus sle, long recognised by clinicians, is now challenging the entire lupus community, from geneticists to clinical investigators. Download pdf open epub full article content list abstract. However, they have become widely used as diagnostic criteria in clinical situations. Slicc12, the new set of criteria established in 2012 to. We included 56 confirmed sle cases meeting the 1982 acr criteria. Systemic lupus erythematosus is a multiorgan system autoimmune disease with clinical and serological heterogeneity. The slicc 2012 sle classification criteria and the. A mnemonic for sle diagnostic criteria annals of the. In this classification, biopsyconfirmed lupus nephritis with positive antinuclear or antidoublestranded dna antibodies became a standalone criterion. We found that slicc 12 is the classification criterion for sle presenting the. Systemic lupus erythematosus larissa lisnevskaia, grainne murphy, david isenberg systemic lupus erythematosus is a remarkable and challenging disorder. The 2012 revised slicc criteria for classification of.
Reprinted with permission from bertsias gk, salmon je, boumpas dt. Sliccnew criteria of systemic lupus erythematosus journal introduction systemic lupus erythematosus. Systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus michelle petri, 1anamaria orbai, graciela s. The reliability of the systemic lupus international collaborating clinicsamerican college of rheumatology damage. Pdf derivation and validation of the systemic lupus international. However, our patient met the acr criteria for sle which has a sensitivity of 85% and specificity of 95%11 as he had arthralgias, pleural and pericardial effusions, lymphopenia and raised antidsdna, and met 5 out of 11 criteria according to newer systemic lupus international collaboration clinics criteria slicc criteria due to decreased. The acr supports criteria development projects in different topic areas related to rheumatic disease. I offer a mnemonic that contains the 11 categories used by the american college of rheumatology,1from which four or more must be present to diagnose sle. Criteria are cumulative and need not be present concurrently. Systemic lupus diagnostic criteria slicc calculator. Apr 27, 2016 healthdayneither the american college of rheumatology acr nor the systemic lupus international collaborating clinics slicc criteria distinguishes patients with subacute cutaneous lupus. The first classification criteria for sle were developed in 1971, revised in 1982, and adopted by the american college of rheumatology acr in 1997. Healthdayneither the american college of rheumatology acr nor the systemic lupus international collaborating clinics slicc criteria distinguishes patients with. New sle classification criteria reset disease definition.
Correct classification of patients with systemic lupus erythematosus sle is critical for clinical trials and clinical and translational science. Slicc classification criteria for sle current medical. About 20% of the cases begin before the age of 16 years, being classified as juvenileonset systemic. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. The use of slicc and acr criteria to correctly label patients. Slicc 12, the new set of criteria established in 2012 to. Toward new criteria for systemic lupus erythematosusa standpoint. Slicc, systemic lupus international collaborating clinicsamerican college of rheumatology damage index. The most widely used and accepted criteria has been the 1997 acr criteria. Study evaluates slicc12 classification criteria for lupus. This study examined large cohorts of subjects with sle and incomplete lupus erythematosus ile to compare the impact of acr and slicc criteria.
Pdf the systemic lupus international collaborating clinics slicc group revised and validated. The systemic lupus international collaborating clinics. Slicc acr damage index 1996 american college of rheumatology. Validation of the 2017 weighted criteria compared to the 1997. Patients may be labelled as systemic lupus erythematosus sle in their medical records, when in fact they have. Feb 08, 2016 systemic lupus erythematosus, sle, sle nephritis, sle management, sle classification, acr vs slicc criteria, new drugs in sle. We compared the european league against rheumatism eularamerican college of rheumatology acr2019, systemic lupus international collaborating clinics slicc2012 and acr1997 criteria in an early median 48 months systemic lupus erythematosus sle cohort. The systemic lupus international collaborating clinics slicc. Therapeutic opportunities in systemic lupus erythematosus. Diagnostic criteria for systemic lupus erythematosus. These criteria are useful and give consistency in the.
Slicc is dedicated to generating new knowledge in the field of lupus, and translating these basic and clinical research discoveries into better health care practices and policies to help provide a healthier future for people diagnosed with lupus. According to the slicc rule for the classification of sle, the patient must satisfy at least 4 criteria. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. The slicc criteria for sle classification requires. Methods patients who had undergone avise ctd testing were assessed for sle diagnosis by the systemic lupus international collaborating clinics slicc and american college of rheumatology criteria and for sle damage by the systemic lupus international collaborating clinics damage index sdi at the time of avise testing t0 and 2 years later t2. Using the data up to v0, we determined the dates at which the acr and slicc criteria were first met. Its diversity of clinical features is matched by the complexity of the factors genetic, hormonal, and environmental that cause it, and the array of autoantibodies with which it is associated. Validation of proposed eularacr sle classification criteria. The formulation of initial criteria for sle was first proposed by the american college of rheumatology and appeared in 1971.
Download as pptx, pdf, txt or read online from scribd. In 2012, the systemic lupus international collaborating clinics slicc 12 published a new set. Projects generally focus on classification, response, and remission criteria. A comparison of three classification criteria sets for. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.